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出版物・論文/研究

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  • 研究

2022年
Hanai S, Terasawa T, Iwata M. Asymptomatic entrapped denture in the hypopharynx. BMJ Case Reports CP 2022;15:e248487.

Shimizu T, Graber M. How insight contributes to diagnostic excellence. Diagnosis (Berl). 2022 Jun 8. doi: 10.1515/dx-2022-0007.

Harada T, Harada Y, Morinaga K, Hirosawa T, Shimizu T. Bandemia as an Early Predictive Marker of Bacteremia: A Retrospective Cohort Study. Int J Environ Res Public Health. 2022 Feb 17;19(4):2275.

Shimizu T. System 2 Diagnostic Process for the Next Generation of Physicians: “Inside” and “Outside” Brain-The Interplay between Human and Machine. Diagnostics (Basel). 2022 Jan 30;12(2):356.

Kawamura R, Harada Y, Sugimoto S, Nagase Y, Katsukura S, Shimizu T. Incidence of Diagnostic Errors Among Unexpectedly Hospitalized Patients Using an Automated Medical History–Taking System With a Differential Diagnosis Generator: Retrospective Observational Study. JMIR Med Inform 2022;10(1):e35225

Harada T, Watari T, Watanuki S, Hiroshige J, Kushiro S, Miyagami T, Syusa S, Suzuki S, Hiyoshi T, Hasegawa S, Nabeshima S, Aihara H, Yamashita S, Tago M, Yoshimura F, Kunitomo K, Tsuji T, Hirose M, Tsuchida T, Shimizu T. Diagnostic error rates and associated factors for lower gastrointestinal perforation. Sci Rep. 2022 Jan 19;12(1):1028.

Kakimoto S, Harada Y, Shimizu T. Mullerian Duct Cyst Infection. J Gen Intern Med. 2022 Jul 5. doi: 10.1007/s11606-022-07710-2.

Otaka Y, Harada Y, Shimizu T. Hypertrophic pachymeningitis in the context of the treatment of polymyalgia rheumatica. BMJ Case Rep. 2022 Jun 20;15(6):e250450.

Yoshida Y, Harada Y, Shimizu T. Costochondral gout. CMAJ. 2022 Jun 20;194(24):E845.

Otaka Y, Harada Y, Shimizu T. Case of bilateral Bell’s palsy. BMJ Case Rep. 2022 Jun 10;15(6):e250364.

Kakimoto S, Harada Y, Shimizu T. Periorbital Necrotizing Fasciitis. J Gen Intern Med. 2022 Mar 18. doi: 10.1007/s11606-022-07484-7.

Sakamoto T, Asahara D. Shimizu T. Intercostal retraction with pleural effusion. Ann Intern Med: Clinical Cases. In Press 2022

Kakimoto S, Harada Y, Shimizu T. Oral stings by spermatophores of a squid. QJM. 2022 Mar 22;115(3):175-176.

2021年
Kawamura R, Harada Y, Shimizu T. Diagnostic Effect of Consultation Referral from Gastroenterologists to Generalists in Patients with Undiagnosed Chronic Abdominal Pain: A Retrospective Study. Healthcare 2021;9(9):1150.

Hirosawa T, Harada Y, Ikenoya K, Kakimoto S, Aizawa Y, Shimizu T. The Utility of Real-Time Remote Auscultation Using a Bluetooth-Connected Electronic Stethoscope: Open-Label Randomized Controlled Pilot Trial. JMIR Mhealth Uhealth 2021;9(7):e23109. doi: 10.2196/23109

Harada Y, Katsukura S, Kawamura R, Shimizu T. Effects of a Differential Diagnosis List of Artificial Intelligence on Differential Diagnoses by Physicians: An Exploratory Analysis of Data from a Randomized Controlled Study. Int J Environ Res Public Health. 2021 May 23;18(11):5562.

Shimizu T. The 6C model for accurately capturing the patient’s medical history. Diagnosis (Berl). 2021 Apr 23. doi: 10.1515/dx-2020-0126.

Harada Y, Katsukura S, Kawamura R, Shimizu T. Efficacy of Artificial-Intelligence-Driven Differential-Diagnosis List on the Diagnostic Accuracy of Physicians: An Open-Label Randomized Controlled Study. Int J Environ Res Public Health. 2021 Feb 21;18(4):2086.

Hirosawa T, Harada Y, Nishinobu T, Honda Y, Morinaga K, Takase H, Shimizu T. The diagnostic value of Reversed Carnett’s sign for detecting intra-abdominal lesion in patients with acute abdominal pain. JHGM. 2021;3(1):11-20.

Harada T, Shimizu T. Fitz-Hugh-Curtis syndrome without salpingitis: Should contrast-enhanced computed tomography be a routine diagnostic procedure? Clin Case Rep. 2021 Dec 13;9(12):e05211.

Kakimoto S, Harada Y, Shimizu T. Acute upper airway obstruction by a goitre due to Hashimoto’s thyroiditis. BMJ Case Rep. 2021 Sep 8;14(9):e245198.

Kunitomo K, Shimizu T, Harada Y. A case of multiple ring-shaped aphthae without pseudomembranous colitis. Am J Med Sci. 2021 Aug 15:S0002-9629(21)00284-6.

Kawamura R, Suzuki Y, Harada Y, Shimizu T. Atypical presentation of colorectal carcinoma with sole multiple osteolytic bone metastases: a case report. J Med Case Rep. 2021 May 21;15(1):256.

Ito T, Harada Y, Shimizu T. Diagnostic and management errors in an immunodeficient patient with pneumococcal pneumonia with bacteremia due to incorrect assessment of the patient’s immune status. Eur J Case Rep Intern Med. 2021; 2 doi:10.12890/2021_002557.

Sakamoto T, Kaburaki M, Shimizu T. Salt-and-pepper skin appearance & Systemic sclerosis. QJM. 2021 May 6:hcab070. doi:10.1093/qjmed/hcab070

Yokose M, Shimizu T. A Case of Ramsay Hunt Syndrome That Began with Vestibular Symptoms: A Great Mimicker. Am J Med. 2021 Apr;134(4):e271-e272. doi:10.1016/j.amjmed.2020.09.049

Ito T, Harada Y, Shimizu T. Diagnostic and Management Errors in an Immunodeficient Patient with Pneumococcal Pneumonia with Bacteraemia due to Incorrect Assessment of the Patient’s Immune Status. Eur J Case Rep Intern Med. 2021 Apr 26;8(4):002557. doi:10.12890/2021_002557

Harada T, Sasaki Y, Tokunaga T, Yoshizawa A, Miura S, Ikeda K, Saito T, Hiroshige J. 18F-Fluorodeoxyglucose positron emission tomography computed tomography detection of single organ vasculitis of the breast: A case report. Medicine (Baltimore). 2021 Mar 26;100(12):e25259. doi:10.1097/MD.0000000000025259

Harada T, Harada Y, Shimizu T. Vertebral Artery Dissection after Exposure to Levofloxacin: A Report of Two Cases. Intern Med. 2021 Mar 22. doi:10.2169/internalmedicine.6736-20

Masuda M, Sakamoto T, Shimizu T. Wellens’ Syndrome. Am J Med Sci. 2021 Feb 20:S0002-9629(21)00066-5. doi:10.1136/bcr-2016-217175.

Kawamura R, Harada Y, Shimizu T. Missed Diagnosis of Cholangiocarcinoma Presenting with Atypical Symptoms. Eur J Case Rep Intern Med. 2021 Jan 26;8(1):002207. doi:10.12890/2021_002207.

2020年
Shimizu T. PERSPECTIVE: AI IN DIAGNOSTIC MEDICINE. 2020 Sep 18. Arerugi.2020;69(8):658-661 doi: 10.15036/arerugi.69.658.

Shimizu T. Horizontal and vertical tracing: a cognitive forcing strategy to improve diagnostic accuracy. Postgrad Med J. 2020 Oct;96(1140):581-583. doi:10.1136/postgradmedj-2020-137548

Harada Y, Shimizu T. Impact of a Commercial Artificial Intelligence-Driven Patient Self-Assessment Solution on Waiting Times at General Internal Medicine Outpatient Departments: Retrospective Study. JMIR Med Inform. 2020 Aug 31;8(8):e21056. doi:10.2196/21056

Hirosawa T, Harada Y, Morinaga K, Takase H, Nin M, Shimizu T. Eosinopenia as a diagnostic marker of bloodstream infection in a general internal medicine setting: a cohort study. BMC Infect Dis. 2020 Jan 30;20(1):85. doi:10.1186/s12879-020-4814-5

Harada Y, Masuda M, Hirosawa T, Takase H, Morinaga K, Nin M, Shimizu T. Safety and efficacy of outpatient follow-up for referred patients with undiagnosed fever: A retrospective cohort study. Medicine (Baltimore). 2020 Jan;99(5):e18532. doi:10.1097/MD.0000000000018532

Mizusawa K, Shimizu T. Three Cases of Food Poisoning Due to Paralepistopsis acromelalga Diagnosed from an Outbreak of Erythromelalgia. Intern Med. 2020 Dec 22. doi:10.2169/internalmedicine.4650-20

Ito T, Sawachika H, Harada Y, Shimizu T. The Dangers of Immediately Performing a Sensitive and Specific Investigation versus the Dangers of Delaying It: A Cautionary Case of Hodgkin’s Lymphoma. Eur J Case Rep Intern Med. 2020 Dec 1;7(12):002138. doi:10.12890/2020_002138

Sakamoto T, Harada Y, Shimizu T. A cat-and-mouse game? Multiple abscesses due to Staphylococcus aureus bacteremia. Am J Med. 2020 Nov 24:S0002-9343(20)31048-2. doi:10.1016/j.amjmed.2020.10.027

Harada T, Watari T, Miyagami T, Watanuki S, Shimzu T, Hiroshige J. COVID Blindness: Delayed Diagnosis of Aseptic Meningitis in the COVID-19 Era. Eur J Case Rep Intern Med. 2020 Oct 23;7(11):001940. doi:10.12890/2020_001940

Harada Y, Shimizu T. Delayed Diagnosis of Pulmonary Thromboembolism Due to Overfocus on COVID-19. Eur J Case Rep Intern Med. 2020 Oct 21;7(11):002002. doi:10.12890/2020_002002

Shimizu T. Elderly woman with swollen leg. J Am Coll Emerg Physicians Open. 2020 Sep 7;1(5):1149-1150. doi:10.1002/emp2.12249

Harada Y, Kakimoto S, Shimizu T. Pazopanib-associated interstitial lung disease in a patient with renal cell carcinoma. BMJ Case Rep. 2020 Jul 8;13(7):e235177. doi:10.1136/bcr-2020-235177

Shimizu T. Synchronous Bilateral Spontaneous Pneumothorax. Am J Med Sci. 2020 Jun 7:S0002-9629(20)30248-2. doi:10.1016/j.amjms.2020.06.006

Hirosawa T, Sakamoto T, Shimizu T. Gastric Anisakiasis. Am J Med Sci. 2020 Sep;360(3):318-319. doi:10.1016/j.amjms.2020.04.021

Hirosawa T, Shimizu T. Brachiocephalic Vein Thrombosis. Am J Med Sci. 2020 May;359(5):306-307. doi:10.1016/j.amjms.2019.12.006

Yokose M, Harada Y, Shimizu T. Behind the Leg: Cryptococcal Meningitis, Not Cellulitis. Am J Med. 2020 Mar;133(3):e81-e82. doi:10.1016/j.amjmed.2019.06.015

Hirosawa T, Katsukura S, Shimizu T. SAPHO Syndrome. Am J Med Sci. 2020 Jan;359(1):e5-e6. doi:10.1016/j.amjms.2019.07.010

2019年
Shimizu T. Reflection Of Reflections: Building Diagnostic Expertise. Int J Gen Med. 2019 Oct 7;12:363-365. doi:10.1016/j.semcdb.2021.02.004

Takase H, Shimizu T. Erythema nodosum-like lesion on heel in a patient assumed Behçet’s disease. BMJ Case Rep. 2019 Nov 19;12(11):e232056. doi:10.1136/bcr-2019-232056

Sakamoto T, Takase H, Shimizu T. Secretion from umbilicus. BMJ Case Rep. 2019 Aug 15;12(8):e231139. doi:10.1136/bcr-2019-231139

Shimizu T, Harada Y. Preauricular Vertical Creases. Intern Med. 2019 Oct 15;58(20):3067. doi:10.2169/internalmedicine.2606-19

Hirosawa T, Shiinoki M, Shimizu T. Cerebral Venous Thrombosis. Am J Med Sci. 2019 Jul;358(1):e3. doi:10.1016/j.amjms.2019.03.001

Harada Y, Hayashi M. Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis. BMJ Case Rep. 2019 Jan 10;12(1):bcr-2018-226514. doi:10.1136/bcr-2018-226514

2018年
Shimizu T, Nemoto T, Tokuda Y. Effectiveness of a clinical knowledge support system for reducing diagnostic errors in outpatient care in Japan: A retrospective study. Int J Med Inform. 2018 Jan;109:1-4. Int J Med Inform. 2018 Jan;109:1-4. doi: 10.1016/j.ijmedinf.2017.09.010. Epub 2017 Sep 25.

Harada Y, Komori I, Morinaga K, Shimizu T. Microangiopathic haemolytic anaemia with thrombocytopenia induced by vitamin B12 deficiency long term after gastrectomy. BMJ Case Rep. 2018 Sep 19;2018:bcr2018225915. doi: 10.1136/bcr-2018-225915.

Amano M, Shimizu T. Mondor’s Disease: A Review of the Literature. Intern Med. 2018 Sep 15;57(18):2607-2612. doi: 10.2169/internalmedicine.0495-17. Epub 2018 May 18.

Jinno A, Hirosawa T. Aortic intramural haematoma associated with pulmonary artery periadventitial haematoma. BMJ Case Rep. 2018 May 18;2018:bcr2018224853. doi: 10.1136/bcr-2018-224853.

Jinno A, Hirosawa T, Shimizu T. Hepatic portal venous gas after diving. BMJ Case Rep. 2018 Jan 12;2018:bcr2017223844. doi: 10.1136/bcr-2017-223844.

Nishizaki Y, Shinozaki T, Kinoshita K, Shimizu T, Tokuda Y. Awareness of Diagnostic Error among Japanese Residents: a Nationwide Study. J Gen Intern Med. 2018 Apr;33(4):445-448. doi: 10.1007/s11606-017-4248-y. Epub 2017 Dec 18.

Hirosawa T, Shimizu T. Osmotic Demyelination Syndrome due to Hyperosmolar Hyperglycemic State. Cleve Clin J Med. 2018 Jul;85(7):511-513. doi: 10.3949/ccjm.85a.17020.

Shimizu T. Severe Hyperkyphosis. Intern Med. 2018 Aug 1;57(15):2281. doi: 10.2169/internalmedicine.0074-17. Epub 2018 Mar 9.

Kamijo C, Harada Y. Delayed Diagnosis of Cast Nephropathy. Am J Med. 2018 Jan;131(1):e23. doi: 10.1016/j.amjmed.2017.07.031. Epub 2017 Aug 12.

2017年
Shimizu T, Nemoto T, Tokuda Y. Effectiveness of a clinical knowledge support system for reducing diagnostic errors in outpatient care in Japan: A retrospective study. Int J Med Inform. 2017:109:1-4. doi: 10.1016/j.ijmedinf.2017.09.010. Epub 2017 Sep 25.

Morinaga K, Yamanaka K. Concomitant crystal-induced and septic arthritis. IDCases. 2017 Jun 27;9:97. doi: 10.1016/j.idcr.2017.04.018. eCollection 2017.

Morinaga K, Shimizu T. Bilateral tarsal tunnel syndrome. Am J Med. 2017 Oct;130(10):e437-e438. doi: 10.1016/j.amjmed.2017.05.009. Epub 2017 Jun 8.

Shibaike Y, Hirosawa T, Shimizu T. Shell in the rectum. BMJ Case Rep. 2017 Jul 5;2017:bcr2017221125. doi: 10.1136/bcr-2017-221125.

Harada T, Hirosawa T, Morinaga K, Shimizu T. Metoclopramide-induced Serotonin Syndrome. Intern Med. 2017;56(6):737-739. doi: 10.2169/internalmedicine.56.7727.

Harada T, Suyama Y, Hiratsuka Y, Shimizu T. An Arterial Perihepatic Enhancement Caused by Spontaneous Bladder Rupture. Urology . 2017 Feb;100:e7-e8. doi: 10.1016/j.urology.2016.11.036. Epub 2016 Nov 25.

Hirose K, Hirosawa T, Shimizu T. Unilateral cutaneous congestion induced by Valsalva manoeuvre due to vascular malformation. BMJ Case Rep. 2017 Mar 9;2017:bcr2017219625. doi: 10.1136/bcr-2017-219625.

2016年
Hirosawa T, Shimizu T, Isegawa T, Tanabe M. Left pleural effusion caused by pancreaticopleural fistula with a pancreatic pseudocyst. BMJ Case Rep. 2016 Aug 24;2016:bcr2016217175. doi: 10.1136/bcr-2016-217175.

Mizuno A, Tsugawa Y, Shimizu T, Nishizaki Y, Okubo T, Tanoue Y, Konishi R, Shiojiri T, Tokuda Y. The Impact of the Hospital Volume on the Performance of Residents on the General Medicine In-Training Examination: A Multicenter Study in Japan. Intern Med. 2016;55(12):1553-8.doi: 10.2169/internalmedicine.55.6293. Epub 2016 Jun 15.

Harada Y. Transient T-wave change in Guillain-Barré syndrome. J Gen Fam Med. 2017 Jun 21;18(6):460-461. doi: 10.1002/jgf2.106. eCollection 2017 Dec.

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研究情報の公開について(オプトアウト)

通常、臨床研究を実施する際には、文書もしくは口頭で説明・同意を得て実施をしますが、臨床研究のうち、患者さまへの侵襲及び介入を伴わず、診療情報等の情報のみを用いた研究等については、国が定めた指針に基づき「研究対象となる患者さまのお一人ずつから文書または口頭による同意を得る必要はありません」とされています。しかし、その際は研究の目的を含めて研究の実施についての情報を公開し、さらに拒否の機会を保障することが必要とされます。このような手法を「オプトアウト」と言います。

オプトアウトを用いた臨床研究は下記の通りです。尚、研究への協力を希望されない場合は、下記文書内に記載されている各研究の担当者までお知らせください。

獨協医科大学病院 総合診療科で実施の研究一覧

研究課題名
大学病院総合診療科に院内他科から紹介される患者の診断に関する横断研究
大学病院入院中に院内他科から総合診療科へ行われるコンサルテーションの内容と結果に関する横断研究
大学病院総合診療科における診断エラー検証のための後ろ向き観察研究
熱源不明の症例に対する感染性心内膜炎の予測モデルの開発:多施設後ろ向き観察研究
獨協医科大学病院における黄色ブドウ球菌菌血症に対する治療介入の質の評価と介入の要否及び方法の検討
獨協医科大学総合診療科外来において鉄欠乏症の治療を行った患者における貧血伴う群と伴わない群の患者背景と臨床経過に関する
後ろ向き観察研究
獨協医科大学病院総合診療科の外来と入院における漢方処方の比較に関する観察研究
総合診療科の連携診療における眼病変から全身性疾患を疑う患者の診断および治療に関する観察研究
血液培養検査を施行した外来患者における血液培養陽性の関連因子に関するケースコントロール研究

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